Peer Reviewed Publications
I am happy to provide .pdf reprints by e-mail.
- Stefan Reinelt, Brigitte Koch, Michael Hothorn, Wolfgang Hengstenberg, Stefan Welti and Klaus Scheffzek
Structure of the Enterococcus faecalis EIIA(gnt) PTS component
BBRC, 388(4): 626-629, 2009 [PubMed] - Gyula Timinszky*, Susanne Till*, Paul O. Hassa*, Michael Hothorn*, Georg Kustatscher, Bianca Nijmeijer, Julien Colombelli, Matthias Altmeyer, Ernst H. K. Stelzer, Klaus Scheffzek, Michael O. Hottiger and Andreas G. Ladurner
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
Nat Struct Mol Biol, 16(9): 923-929, 2009 [PubMed]
* these authors contributed equally to this work - Michael Hothorn, Heinz Neumann, Esther D. Lenherr, Mark Wehner, Vladimir Rybin, Paul O. Hassa, Andreas Uttenweiler, Monique Reinhardt, Andrea Schmidt, Jeanette Seiler, Andreas G. Ladurner, Christian Herrmann, Klaus Scheffzek and Andreas Mayer
Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase
Science, 324(5926): 513-516, 2009 [PubMed] [Author Manuscript] [Supporting Online Material]
- Lorenzo Corsini, Michael Hothorn, Gunter Stier, Vladimir Rybin, Klaus Scheffzek, Toby J. Gibson, and Michael Sattler
Dimerization and protein binding specificity of the U2AF homology motif (UHM) of the splicing factor Puf60
J Biol Chem, 284(1): 630-639, 2009 [PubMed], [free full-text] - Lorenzo Corsini, Michael Hothorn, Klaus Scheffzek, Michael Sattler and Gunter Stier
Thioredoxin as a fusion-tag for carrier-driven crystallization
Protein Science, 17(12): 2070-2079, 2008 [PubMed], [free full-text] - Tobias Stuwe*, Michael Hothorn*, Erwane Lejeune, Vladimir Rybin, Miriam Bortfeld, Klaus Scheffzek and Andreas G. Ladurner
The FACT Spt16 "peptidase" domain is a histone H3 H4 binding module
PNAS, 105(26): 8884-8889, 2008 [Pubmed], [free full-text]
* these authors contributed equally to this work - Roland Gromes, Michael Hothorn, Esther D. Lenherr, Vladimir Rybin, Klaus Scheffzek and Thomas Rausch
Redox-switch of gamma-glutamylcysteine ligase via reversible monomer-dimer transition is a mechanism unique to plants
Plant Journal, 54(6):1063-1075, 2008 [Pubmed] - Vladimir Pena, Michael Hothorn, Alexander Eberth, Nikolai Kaschau, Annabel Parret, Lothar Gremer, Fabien Bonneau, Mohammad Rheza Ahmadian and Klaus Scheffzek
The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction
EMBO Reports, 9(4):350-355, 2008 [PubMed], [free full-text] - Susanne Till, Erwan Lejeune, Rolf Thermann, Miriam Bortfeld, Michael Hothorn, Daniel Enderle, Constanze Heinrich, Matthias W Hentze and Andreas G. Ladurner
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain
Nat Struct Mol Biol, 14(10): 897-903, 2007 [PubMed] - Lorenzo Corsini, Sophie Bonnal, Jerome Basquin, Michael Hothorn, Klaus Scheffzek, Juan Valcarcel and Michael Sattler
U2AF-homology motif interactions are required for alternative splicing regulation by SPF45
Nat Struct Mol Biol, 14(7): 620-29, 2007 [PubMed] - Hannes Simader, Michael Hothorn and Dietrich Suck
Structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA-aminoacylation and nuclear-export cofactor Arc1p reveal a novel function for an old fold
Acta Crystallogr D Biol Crystallogr, 62: 1510-19, 2006 [PubMed] - Hannes Simader, Michael Hothorn, Christine Kohler, Jerome Basquin, George Simos and Dietrich Suck
Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes
Nucleic Acids Res, 34(14): 3968-79, 2006 [PubMed], [free full-text] - Michael Hothorn, Andreas Wachter, Roland Gromes, Tobias Stuwe, Thomas Rausch and Klaus Scheffzek
Structural basis for the redox-control of plant glutamate cysteine ligase
J Biol Chem, 281(37): 27557-65, 2006 [PubMed], [free full-text] - Michael Hothorn and Klaus Scheffzek
Multiple crystal forms of the cell-wall invertase inhibitor from tobacco support high conformational rigidity over a broad pH range
Acta Crystallogr D Biol Crystallogr, 62(Pt 6): 665-70, 2006 [PubMed] - Georg Kustatscher*, Michael Hothorn*, Celine Pugieux, Klaus Scheffzek and Andreas G. Ladurner
Splicing regulates NAD metabolite binding to histone macroH2A
Nat Struct Mol Biol, 12(7): 624-25, 2005 [PubMed]
* these authors contributed equally to this work - Michael Hothorn, Sebastian Wolf, Patrick Aloy, Steffen Greiner and Klaus Scheffzek
Structural insights into the target specificity of plant invertase and pectin methylesterase inhibitory proteins
Plant Cell, 16(12): 3437-47, 2004 [PubMed], [free full-text] - Michael Hothorn, Igor D'Angelo, Jose Antonio Marquez, Steffen Greiner and Klaus Scheffzek
The invertase inhibitor Nt-CIF from tobacco: a highly thermostable four-helix bundle with an unusual N-terminal extension
J Mol Biol, 335(4): 987-95, 2004 [PubMed] - Michael Hothorn, Fabien Bonneau, Gunter Stier, Steffen Greiner and Klaus Scheffzek
Bacterial expression, purification and preliminary X-ray crystallographic characterization of the invertase inhibitor Nt-CIF from tobacco
Acta Crystallogr D Biol Crystallogr, 59(Pt 12): 2279-82, 2003 [PubMed]
Thesis work
Ph.D. thesis
"Crystallographic studies on protein regulatory mechanisms"
European Molecular Biology Laboratory and University of Heidelberg, Germany, 2006
summa cum laude (with destinction)
Diploma thesis
"Expression, characterisation and crystallisation of a tobacco apoplasmic invertase inhibitor"
Ruperto-Carola University of Heidelberg, Germany, 2002
(with destinction)